MULTIPLE MYELOMA (MM)

CAT.# FP-021: RB1 GENE DELETION PROBE

IVD/RUO

BACKGROUND

RB1 gene is located in the 13q14.2 region, its encoded protein acts as a tumor suppressor and plays a very important role in cell cycle and genomic DNA stability.

PROBE DESCRIPTION

RB1 gene deletion detection probe uses an orange-red fluorescent label RB1 gene, and the RB1 probe bind to the target detection site by in situ hybridization. This method is used to detect the abnormalities in multiple myeloma genes, and provide clinical reference for the differentiation, prognosis and medication for leukemia patients.

CLINICAL SIGNIFICANCE 

Some researchers recommend MM differential diagnosis at the cytogenetic level. These changes are closely related to the prognosis of patients. Patients with RB1 gene deletion have a moderate prognosis with a median survival of 40 months.

RB1 DELETION [--]
RB1 DELETION [+]

     References

  • Chang H, et al. (2010) Bone Marrow Transplant 45: 117-21.
  • Kulkarni MS, et al. (2202) Leukemia 16:127-34.
  • Walker BA, et al. (2010) Blood 116: 56-65.
  • Shaughnessy J, et al. (2005) Hematology 10: 117-26.
  • Zhan F, et al. (2007) Blood 109: 4995-5001.
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