BLADDER CANCER
CAT.# FP-014-2: P53 GENE PROBE
IVD/RUO
BACKGROUND
The P53 gene is highly correlated with human tumors and is an important tumor suppressor gene. The 53kD protein encoded by the P53 gene plays an important regulatory role in the cell cycle, and has a growth inhibitory effect under normal conditions, and plays an important role in DNA cell damage response, cell death and differentiation in the cell cycle.
PROBE DESCRIPTION
P53 gene amplification probe uses an orange-red dye to label the P53 gene region, and a green dye to label chromosome 17 centromere region (CEP17). P53 gene marker region is located at 17q13.1, and the CEP17 probe is labeled with a specific alpha satellite sequence.
CLINICAL SIGNIFICANCE
P53 gene amplification and deletion indicate tumor poor prognosis, its insensitivity to conventional chemotherapy, and is inclined to metastasis.
References
- Chang H, et al. (2010) Am J Clin Pathol 133: 70-4.
- Herrera JC, et al. (2010) Biomedica 30: 390-400.
