P16 gene is located on the 9p21 chromosome and is a tumor suppressor gene. P16 gene deletion is present in 10% of ALL patients and has a higher proportion in T-ALL. Currently, FISH technology is widely used in the diagnosis of P6 gene deletion in ALL.
PROBE DESCRIPTION
P16 gene deletion probe uses an orange-red dye to label P16 gene region, and a green dye is to label chromosome 9 centromere region (CEP9).
CLINICAL SIGNIFICANCE
One of the most common abnormalities in ALL is that homozygous deletions are mostly in T-ALL, and the proportion of homozygotes and heterozygotes in B-ALL is comparable; the prognosis is poor.
References
Fry et al., Mol Cancer Ther. 2004 Nov;3(11):1427-38
Fry et al., Mol Cancer Ther. 2004 Nov;3(11):1427-38