NEUROBLASTOMA
CAT.# FP-048: N-MYC GENE AMPLIFICATION PROBE
IVD/RUO
BACKGROUND
MYCN gene is located in the p24.3 region of chromosome 2 and encodes a 62-64 kDa transcription factor. MYCN is mainly expressed in the nervous system.
PROBE DESCRIPTION
MYCN gene amplification probe uses an orange-red dye to mark the MYCN gene region, and a green dye to label the chromosome 2 centromere region (CEP2). The MYCN gene marker region is located at 2p24.3, and the CEP2 probe is labeled with a specific alpha satellite sequence.
CLINICAL SIGNIFICANCE
MYCN gene amplification occurs in approximately 25% of patients with neuroblastoma. MYCN gene amplification is associated with infiltration, metastasis and poor prognosis of neuroblastoma. When the MYCN gene amplification factor is less than 10, the clinical treatment plan may not be treated after the complete removal of the primary tumor; when the MYCN gene amplification factor is >10, the conventional chemotherapy should be performed for 12 months after the surgical resection, and local radiotherapy is needed if necessary.
References
- Gessi M, et al. (2014) Neuro Oncol 16: 924-32.
- Suita S, et al. (2007) J Pediatr Surg 42: 489-93.
