LYMPHOMA
CAT.# FP-234-3: MYC/IGH GENE FUSION PROBE
IVD/RUO
BACKGROUND
MYC proto-oncogene is located on chromosome 8q24, and its encoded transcription factors are closely related to cell growth and proliferation, as well as tumorigenesis. Translocation of the MYC gene is considered to be a cytogenetic marker of Burkitt’s lymphoma (BL), but is also present in other types of lymphoma. About 80% of BL cases have a translocation between the c-MYC gene locus and the Ig gene locus (t(8;14) (q24;q32)), ie, the high activity of the c-MYC translocation to the Ig locus, thus constituting a highly active genes rearrangement, initiating c-MYC transcription, enhancing c-MYC expression, promoting malignant transformation, and ultimately leading to tumorigenesis. The t(8;14) (q24;q32) test helps to diagnose Burkitt’s lymphoma and can guide the treatment of high-grade B-cell lymphoma.
PROBE DESCRIPTION
MYC /IGH is a dual-color, double-fusion probe consisting of a green fluorescent directly labeling IGH probe across known IGH breakpoint, and an orange-red fluorescence directly labeling MYC probe across known MYC breakpoint.
CLINICAL SIGNIFICANCE
T(8;14) can be used to assist in the diagnosis of Burkitt’s lymphoma – BL- (75% incidence) and guide the treatment of high-grade B lymphoma the prognosis is poor.
References
- May P, et al. (2010) Cancer Genet Cytogenet 198: 71-5.
- Perkins A, et al. (2008) Hematology Am Soc Hematol Educ Program 2008: 341-8.
- Veronese ML, et al. (1995) Blood 85: 2132-8.
