BREAST CANCER

CAT.# FP-015: MYC GENE AMPLIFICATION PROBE DETECTION KIT

IVD/RUO

BACKGROUND

The MYC proto-oncogene is located on chromosome 8q24 and encodes a transcription factor that regulates cell growth. It is activated mainly by amplification and chromosome translocation rearrangement. MYC gene amplification is associated with the development of a variety of tumors (including breast cancer, colon cancer, lung cancer, hematopoietic tumors, etc.).

PROBE DESCRIPTION

MYC gene amplification probe uses orange-red dye to label MYC gene region, and green dye to label chromosome 8 centromere region (CEP8). The MYC gene marker region is located at 8q24.21, and the CEP8 probe is labeled with a specific alpha satellite sequence.

CLINICAL SIGNIFICANCE

MYC gene amplification is a common phenomenon in tumors and can be found in a variety of malignant tumors such as breast cancer, nasopharyngeal cancer, and cervical cancer. The prognosis of breast cancer patients with MYC gene amplification is poor.

MYC amplification [+]
MYC amplification [--]

     References

  • Fromont G, et al. (2013) Hum Pathol 44:1617-23.
  • Mannuci S, et al. (2012) Adv Hematol 2012:149780
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