ACUTE LYMPHOCYTIC LEUKEMIA

CAT.# FP-242-3: IGH GENE BREAK APART PROBE

IVD/RUO

BACKGROUND

IGH separated dual-color probe aims to detect the translocation of 14q32.33 chromosome region (i.e., the IGH gene). IGH gene rearrangement is found in about 50% of NHLs (non-Hodgkin’s lymphoma), and also in T-ALL, CLL and ALL. Studies have shown that IGH gene translocation also occurs in children’s T-ALL.

PROBE DESCRIPTION

5’end of IGH gene region is labeled with an orange-red fluorescein, and the 3’end labeled with a green fluorescein. The translocation of 14q32 region is detected with IGH gene break probe. All IGH gene rearrangements can be detected and avoiding separate detection due to missed diagnosis caused by gene fusion.

CLINICAL SIGNIFICANCE 

In ALL, the ratio of IGH to C-MYC translocation is the highest. In B-ALL and T-ALL, translocation of IGH with other genes is also more common.

IGH BREAK APART [--]
IGH BREAK APART [+]

     References

  • Bernicot I, et al. (2007) Cytogenet Genome Res 118: 345-52.
  • Hehne S, et al. (2012) Pathol Res Pract 208: 510-7.
  • Quintero-Rivera F, et al. (2009) Cancer Genet and Cytogenet 190: 33-9.
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