ACUTE LYMPHOCYTIC LEUKEMIA

CAT.# FP-031: CHROMOSOME 17 PROBE

IVD/RUO

BACKGROUND

About 25% of children with ALL have an increase in the number of chromosomes, and chromosomes 4, 5, 6, 10, 17 and 21 are more common, among which trisomy 10 is the most common.

PROBE DESCRIPTION

Chromosome is labeled with a green fluorescein. In normal cells, two green signals are observed under fluorescence microscopy. When chromosome number abnormality exists, three green signals are observed.

CLINICAL SIGNIFICANCE

The 17 trisomy is an independent prognostic indicator, and these patients have a 7-years EFS greater than 90%. The method of detecting the number of CEP17 chromosome provides a reference for the clinical identification, prognosis and medication of leukemia patients.

References

Felice et al., Leuk Lymphoma. 2011 Jul;52(7):1215-21.
Savage et al., Blood. 2009 Oct 22;114(17):3533-7.