Trisomy 13 is the most common chromosome number abnormality in chronic lymphocytic leukemia (CLL), with an incidence of 40%-60%. It is often characterized by unique cytogenetic abnormalities. Among other genetic disorders, patients with trisomy 12 are considered to be at low risk.
PROBE DESCRIPTION
The centromere region of chromosome 12 is directly labeled with a green fluorescent dye.
CLINICAL SIGNIFICANCE
Chromosome 12 trisomy is the most common chromosome number abnormality in B-CLL, with an abnormal proportion of more than 55%. The total survival time of trisomy 12 decreases and needs early treatment.
References
Swerdlow et al., editors, WHO Classification of Tumours of Haematopoietic and