LYMPHOMA
CAT.# FP-233-1: cCND1 (BCL1)/IGH GENE FUSION PROBE
IVD/RUO
BACKGROUND
CCND1/IGH dual-color fusion probe is used to detect t(11;14) (q13.3; q32.3) translocations in up to 95% of mantle cell lymphomas (MCLs). At the same time, t(11;14) is also present in other lymphoproliferative diseases, such as juvenile lymphoblastic leukemia (PLL) and plasma cell myeloma.
PROBE DESCRIPTION
CCND1 probe labeled with an orange-red fluorescent dye and IGH green probe labeled with a green fluorescent dye bound to the target detection site by in situ hybridization. Under normal conditions (CCND1/IGH gene is not fused), it shows two orange-red signals and two green signals under a fluorescence microscope. When there is a gene fusion, the green and orange signals recombine to form yellow fusion signal.
CLINICAL SIGNIFICANCE
Mantle cell lymphoma is a subtype of NHL with poor prognosis; t(11;14)(q13.3;q32.3) can be used for the auxiliary diagnosis of mantle cell lymphoma (MCL). It can also be used for the MCL and CLL differentiation.
References
- Bentz JS, et al. (2004) Cancer 102: 124-31.
- Li JY, et al. (1999) Am J Pathol 154: 1449-52.
