THYROID CANCER

CAT.# FP-041: CCND1 GENE AMPLIFICATION PROBE

IVD/RUO

BACKGROUND

Human CCND1 gene is located in the q13 region of chromosome 11 and encodes cyclin D1. Its main function is to regulate the transition of the cell cycle from the early stage of DNA synthesis (G1 phase) to the DNA synthesis phase (S phase). Overexpression of CCND1 gene will affect the normal cell cycle, leading to a variety of tumor diseases. CCND1 gene amplification is present in thyroid cancer, non-small cell lung cancer, breast cancer, bladder cancer and other tumors.

PROBE DESCRIPTION

CCND1 gene amplification probe uses an orange-red dye to mark CCND1 gene region, and a green dye to label chromosome 11-centromere region (CEP11). CCND1 gene marker region is located at 11q13.3, and the CEP11 probe is labeled with a specific alpha satellite sequence.

CLINICAL SIGNIFICANCE 

CCND1 gene amplification predicts an important role in tumor development. Patients with CCND1 gene amplification have a poor prognosis and are closely related to chemotherapy resistance.

CCND1 AMPLIFICATION [--]
CCND1 AMPLIFICATION [+]

     References

  • Motokura T, et al. (1991) Nature 350: 512-5.
  • Ormandy CJ, et al. (2003) Breast Cancer Res Treat 78: 323-35.
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