MULTIPLE MYELOMA (MM)

CAT.# FP-022: 1q21 GENE AMPLIFICATION PROBE

IVD/RUO

BACKGROUND

Chromosome 1 abnormality is one of the most common cytogenetic findings in MM (Multiple myeloma). A major feature of B cell malignancies is the slow increase in malignant plasma cells grown in the bone marrow. The CKS1B gene is located at 1q21 of chromosome 1 long arm end. In the progression of myeloma disease, tandem repetition and skip translocations of the 1q21 band occur, whereas in patients with multiple myeloma, 1q amplification is associated with poor prognosis.

PROBE DESCRIPTION

1q21 gene amplification detection probe uses an orange-red fluorescent label 1q21 region, and the 1q21 probe binds to the target detection site by in situ hybridization. This method is used to detect abnormalities of multiple myeloma genes, and provide clinical reference for the differentiation, prognosis and medication for leukemia patients.

CLINICAL SIGNIFICANCE 

1q21 (CKS1B) is the most common genetic abnormality in MM. The expansion of CKS1B gene leads to the up-regulation of cell cycle, which causes many proliferative diseases. 1q21 amplification is often associated with MM phenotype infiltration, poor prognosis and rapid disease progress.

1q21 AMPLIFICATION [--]
1q21 AMPLIFICATION [+]

     References

  • Chang H, et al. (2010) Bone Marrow Transplant 45: 117-21.
  • Kulkarni MS, et al. (2202) Leukemia 16:127-34.
  • Walker BA, et al. (2010) Blood 116: 56-65.
  • Shaughnessy J, et al. (2005) Hematology 10: 117-26.
  • Zhan F, et al. (2007) Blood 109: 4995-5001.
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