MULTIPLE MYELOMA (MM)

CAT.# FP-014-2: P53 GENE PROBE

IVD/RUO

BACKGROUND

P53 gene is highly correlated with human tumors and is an important gene tumor suppressor. The 53kD protein encoded by the P53 gene plays an important regulatory role in the cell cycle, and has a growth inhibitory effect under normal conditions, and plays an important role in DNA cell damage response, cell death and differentiation in the cell cycle.

PROBE DESCRIPTION

P53 gene probe uses an orange-red dye to label P53 gene region, and a green dye to label chromosome 17-centromere region (CEP17). P53 gene marker region is located at 17q13.1, and CEP17 probe is labeled with a specific alpha satellite sequence.

CLINICAL SIGNIFICANCE 

P53 deletion occurs in 1/3 of newly diagnosed MM (Multiple myeloma), which means short survival and poor prognosis for patients receiving conventional chemotherapy dose.

P53 DELETION [--]
P53 DELETION [+]

     References

  • Chang H, et al. (2005) Blood 105: 358-60.
  • Chang H, et al. (2010) Am J Clin Pathol 133: 70-4.
  • Herrera JC, et al. (2010) Biomedica 30: 390-400.
  • Lozanski G, et al. (2004) Blood 103: 3278-81.
  • Tavor S, et al. (2011) Leuk Lymphoma 52: 642-7.
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