LYMPHOMA
CAT.# FP-014-2: P53 GENE PROBE
IVD/RUO
BACKGROUND
P53 gene is highly correlated with human tumors and is an important gene tumor suppressor. The 53kD protein encoded by the P53 gene plays an important regulatory role in the cell cycle, has a growth inhibitory effect under normal conditions, and plays an important role in DNA cell damage response, cell death and differentiation in the cell cycle.
PROBE DESCRIPTION
P53 gene probe uses an orange-red dye to label P53 gene region, and a green dye to label chromosome 17-centromere region (CEP17). P53 gene marker region is located at 17q13.1, and CEP17 probe is labeled with a specific alpha satellite sequence.
CLINICAL SIGNIFICANCE
P53 gene deletion indicates patient’s poor response to chemo-radiotherapy and are prone to metastasis, which can be used as an indicator for therapeutic efficacy and prognosis. If p53 gene mutation occurs in the early stage of tumorigenesis, it will be helpful for the tumor early diagnosis.
References
- Chang H, et al. (2010) Am J Clin Pathol 133: 70-4.
- Herrera JC, et al. (2010) Biomedica 30: 390-400.
