CHRONIC LYMPHOCYTIC LEUKEMIA

CAT.# FP-245-3: ATM GENE DELETION PROBE

IVD/RUO

BACKGROUND

ATM gene (ataxia telangiectasia mutated gene) is located at 11q22.3 and encodes a protein kinase involved in cell cycle regulation and activation of TP53 activity.

PROBE DESCRIPTION

ATM gene deletion kit is a dual-color hybrid probe that directly labels ATM probe with an orange-red fluorescent dye. The probe specifically acts on the ATM gene at the chromosome 11q22.3 region, and the chromosome 11 centromere is directly labeled with a green fluorescent dye.

CLINICAL SIGNIFICANCE 

ATM gene deletion has a 15-20% incidence in B cell CLL, which is associated with disease invasiveness and poor prognosis. ATM gene deletion is the most common deletion abnormality in CLL, which can guide the selection of treatment options and prognosis evaluation.

ATM DELETION [--]
ATM DELETION [+]

     References

  • Ripollés L, et al. (2006) Cancer Genet Cytogenet 171: 57-64.
  • Shanafelt TD, et al. (2006) Ann Intern Med 145: 435-47.
  • Stilgenbauer S, et al. (2002) Leukemia 16: 993-1007.
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