CHRONIC LYMPHOCYTIC LEUKEMIA
CAT.# FP-025: D13S319/LAMP1 GENE PROBE
IVD/RUO
BACKGROUND
13q14/13q34 dual-color probe is designed to detect the deletion of the long arm end of chromosome 13. The most common aberration in chronic lymphocytic leukemia (CLL) is the deletion of 13q14.2, which contains the D13S319 gene and has a good prognosis for single genetic variant. Combined with further biomarkers, morphological and clinical applications, fluorescence in situ hybridization (FISH) can be an important tool for predicting disease progression and overall survival in CLL patients.
PROBE DESCRIPTION
13q14/13q34 is a dual-color hybrid probe. The orange-red fluorescent dye directly labels the D13S319 probe and the probe specifically detects the D13S319 gene at 13q14.2. The green fluorescent dye directly labels the 13q34 probe, which specifically detects LAMP1 gene in the 13q34 region.
CLINICAL SIGNIFICANCE
Studies have shown that the deletion of 13q has a negative impact on the survival of patients in event-free survival and overall survival. The most common aberration in CLL is the deletion of 13q14.2, which contains D13S319 gene and has a good prognosis for individual genetic variants. These abnormalities are important for the diagnosis, differential diagnosis, treatment options and prognosis in chronic lymphocytic leukemia.
References
- Chang H, et al. (1999) Leukemia 13: 105-9.
- Dal Bo M, et al. (2011) Genes Chromosomes Cancer 50: 633-43.
- Liu Y, et al. (1998) Blood 86: 1911-15.
