ACUTE LYMPHOCYTIC LEUKEMIA

CAT.# FP-030: CHROMOSOME 4 AND 10 PROBE

IVD/RUO

BACKGROUND

About 25% of children with ALL have an increase in the number of chromosomes, and chromosomes 4, 5, 6, 10, 17 and 21 are more common, among which trisomy 10 is the most common.

PROBE DESCRIPTION

Chromosome 4-centromere region is labeled with an orange-red fluorescein, and the centromere region of chromosomes 10 and 17 is labeled with a green fluorescein. In normal cells, two orange-red signals and two green signals are observed under fluorescence microscopy. When chromosome number abnormality exists, three orange-red signals or three green signals are observed.

CLINICAL SIGNIFICANCE 

The 4, 10, and 17 trisomy are independent prognostic indicators, and these patients have a 7-years EFS greater than 90%. The method of detecting the number of CEP4/CEP10/CEP17 chromosomes provides a reference for the clinical identification, prognosis and medication of leukemia patients.

CEP4/CEP10 (-)
CEP4/CEP10 (+)
CEP 17 (-)
CEP 17 (+)

     References

  • Felice et al., Leuk Lymphoma. 2011 Jul;52(7):1215-21
  • Savage et al., Blood. 2009 Oct 22;114(17):3533-7
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