ACUTE LYMPHOCYTIC LEUKEMIA

CAT.# FP-026: MLL GENE DELETION PROBE

IVD/RUO

BACKGROUND

MLL (Mixed-linage leukemia or Myeloid-lymphoid leukemia) gene located at 11q23 was successfully cloned as early as 1991. The MLL gene is a key gene in the regulation of hematopoietic processes, and its abnormality is closely related to the pathogenesis of leukemia.

PROBE DESCRIPTION

MLL gene 5’end region is labeled with an orange-red fluorescein and the 3’end labeled with a green fluorescein. The translocation of 11q23 region is detected with MLL gene break probe. All MLL gene rearrangements can be detected and avoiding separate detection due to missed diagnosis caused by gene fusion.

CLINICAL SIGNIFICANCE 

MLL gene can fuse with 51 genes after chromosomal translocation. The incidence of MLL gene changes in acute leukemia is about 5%-10%, but in infant ALL it is up to 79%, which is a sign of poor prognosis. EFS in 5 years is only 26.7%.

MLL BREAK APART [--]
MLL BREAK APART [+]

     References

  • Ford DJ & Dingwall AK (2015) Cancer Genet 208: 178-91.
  • Gindin T, et al. (2015) Hematol Oncol 33: 239-46.
  • Keefe JG, et al. (2010) J Mol Diagn 12: 441-52.
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