ACUTE LYMPHOCYTIC LEUKEMIA

CAT.# FP-243-1: MYC GENE BREAK APART PROBE

IVD/RUO

BACKGROUND

MYC proto-oncogene is located on chromosome 8q24 and encodes a transcription factor that regulates cell growth. It is mainly activated by amplification and chromosomal translocation, and its downstream target genes affect cell proliferation, DNA and protein synthesis and metabolism.

PROBE DESCRIPTION

MYC dual-color break apart probe is a two directly labeled hybrid probe that hybridizes at the 8q24.21 region. The probe is directly labeled with an orange-red fluorescent dye that hybridizes with the proximal end of the MYC gene, and with a green fluorescent dye that hybridizes with the distal end of the MYC gene.

CLINICAL SIGNIFICANCE 

Abnormal MYC gene break apart occurs in 5% of B-ALL patients and can fuse with multiple genes. Approximately 75% of mature B-cell acute lymphocytic patients are morphologically characterized by ALL-L3, often accompanied by a typical t(8;14) (q24; q32). Abnormal MYC gene break apart means that the prognosis is extremely poor and clear in clinical practice.

MYC BREAK APART [--]
MYC BREAK APART [+]

     References

  • Boerma EG, et al. (2009) Leukemia 23: 225-34.
  • Haralambieva E, et al. (2004) Genes Chromosomes Cancer 40: 10-8.
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