SOFT TISSUE CANCER

CAT.# FP-055: SS18 GENE BREAK APART PROBE

IVD/RUO

BACKGROUND

SYT (SS18) gene is located in the q11.2 region of chromosome 18 and encodes a transcriptional co-activator. Specific SYT (SS18) gene translocation exists in 90% of synovial sarcomas.

PROBE DESCRIPTION

SYT (SS18) gene break apart probe uses an orange dye to label the 5’end region of SYT (SS18) gene and a green dye to label the 3’end region of SYT (SS18) gene. SYT (SS18) gene break apart probe can detect all SYT (SS18) gene rearrangements.

CLINICAL SIGNIFICANCE 

Specific chromosomal translocation t (X:18) was found in 90% of patients with synovial sarcoma (p11.2: q11.2). This translocation results in the fusion of the SYT (SS18) gene on chromosome 18 with the SSX1 or SSXE gene on the X chromosome. This is used to assist in the diagnosis of synovial sarcoma.

SS18 BRAK APART [--]
SS18 BREAK APART [+]

     References

  • Surace C, et al. (2004) Lab Invest 84: 1185-92.
  • Torres L, et al. (2008) Cancer Genet Cytogenet 187: 45-9.
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