NEUROBLASTOMA

CAT.# FP-050: 1p36(SRD) GENE DELETION PROBE

IVD/RUO

BACKGROUND

Deletion of the 1p36 region (SRD gene) can occur in a variety of tumors, such as neuroblastoma, glioma, leukemia, lymphoma, and the like.

PROBE DESCRIPTION

1p36 (SRD) gene deletion probe uses an orange-red dye to label the SRD gene region, and a green dye to label chromosome 1 centromere region (CEP1). SRD gene marker region is located at 1p36, and the CEP1 probe is labeled with a specific alpha satellite sequence.

CLINICAL SIGNIFICANCE

The deletion of 1p36 (SRD gene) in neuroblastoma is the most typical genetic alteration. The detection of 1p36 heterozygous deletion has a major significance in the clinical guidance and prognosis of neuroblastoma. 1p36 patients with neuroblastoma are prone to recurrence, have a poor prognosis, and are sensitive to chemotherapy.

SRD GENE DELETION [--]
SRD GENE DELETION [+]

     References

  • Elsir T, et al. (2011) Br J Cancer 11: 1747-54.
  • Hoeller S, et al. (2012) Hum Pathol 43: 405-12.
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