NEUROBLASTOMA

CAT.# FP-049: MDM4 GENE AMPLIFICATION PROBE

IVD/RUO

BACKGROUND

MDM4 (HDMX, MDMX) gene is located in the q32.1 region of chromosome 1, encoding a protein containing 490 amino acid residues. MDM4 is an important regulator of p53 upstream and plays a major role in apoptosis.

PROBE DESCRIPTION

MDM4 (HDMX, MDMX) gene amplification probe uses an orange-red dye to label MDM4 gene region, and a green dye to label the chromosome 1 centromere region (CEP1). MDM4 (HDMX, MDMX) gene marker region is located at 1q32.1, and the CEP1 probe is labeled with a specific alpha satellite sequence.

CLINICAL SIGNIFICANCE

MDM4 amplification is seen in 65% of primary neuroblastomas, MDM4 is a primary neuroblastoma-specific chemotherapy target, and MDM4 gene amplification patients are not sensitive to chemotherapy.

MDM4 Amplification [--]
MDM4 Amplification [+]

    References

  • Duhamel LA, et al. (2012) Histopathology 60: 357-9.
  • Laurie NA, et al. (2006) Nature 444: 61-6.
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